Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening.

doi:10.1016/j.bmcl.2015.06.050

Paper

DOI: 10.1016/j.bmcl.2015.06.050

Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening.

Published Sep 1, 2015 · Shridevi D. Doddaramappa, K. L. Lokanatha Rai, N. Srikantamurthy

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Compound 9b, a novel 5-functionalized-pyrazole, shows excellent antimicrobial and antidiabetic activity, with potential applications in pharmaceuticals.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Recent advances in the synthesis and medicinal perspective of pyrazole-based α-amylase inhibitors as antidiabetic agents.

Pyrazine-based -amylase inhibitors show potential as antidiabetic agents due to their synthesis, biological activities, structure-activity relationships, and molecular docking studies.

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Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis

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Design and synthesis of novel pyrazole-phenyl semicarbazone derivatives as potential α-glucosidase inhibitor: Kinetics and molecular dynamics simulation study.

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