Paper

Omeprazole induces vascular remodeling by mechanisms involving xanthine oxidoreductase and matrix metalloproteinase activation.

Published May 28, 2021 · Gustavo H Oliveira-Paula, S. O. Conde, M. Castro

Biochemical pharmacology

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Abstract

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Study Snapshot

Long-term use of omeprazole induces vascular dysfunction and remodeling by promoting oxidative stress and MMP activation, which can be prevented by allopurinol treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Omeprazole induces vascular remodeling by mechanisms involving xanthine oxidoreductase and matrix metalloproteinase activation.

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