Based on our previous studies, 21 new halogenated 3‐(4‐alkylphenyl)‐1,3‐benzoxazine‐2,4‐(3H)‐diones were synthesized by the reaction of salicylanilides and methyl‐chloroformate. All compounds were screened in vitro against three different strains of mycobacterium, and Free‐Wilson method was used to establish structure‐activity relationships. 6‐Bromo‐3‐(4‐butylphenyl)‐1,3‐benzoxazine‐2,4‐(3H)‐dione 3b proved to be the most active compound of the series.

Halogenated 3(4-alkylphenyl)1,3benzoxazine2,4(3H)diones show potential as antituberculotics, with 6Bromo-3(4-butylphenyl)1,3

Paper

The Oriented Development of Antituberculotics (Part II): Halogenated 3‐(4‐Alkylphenyl)‐1,3‐benzoxazine‐2,4‐(3H)‐diones

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