A novel metabolic pathway in the metabolism of 5-(4'-chloro-n-butyl)picolinic acid.

doi:10.1002/BMS.1200030309

Paper

A novel metabolic pathway in the metabolism of 5-(4'-chloro-n-butyl)picolinic acid.

Published Jun 1, 1976 · H. Miyazaki, H. Takayama, Y. Minatogawa

Biomedical mass spectrometry

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13

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Abstract

The metabolism of 5-(4'-chloro-n-butyl)picolinic acid, which inhibits dopamine beta-hydroxylase and exhibits an antihypertensive effect, has been studied by gas chromatography mass spectrometry, utilising characteristic reaction products after derivatization. In rat urine five metabolities were identified by mass spectral analysis. It is found that four were elongated by a C2 unit in the carboxyl group at the 2-position on the pyridine ring and accounted for approximately 50% of the radioactivity in the 24 hour urine. The facts show that the metabolic pathway corresponding to the chain elongation of fatty acids is the major route of metabolism for this drug in the rat. Furthermore, this pathway would be confirmed in man, rabbit, guinea pig and mouse.

In Vitro Study

Study Snapshot

The major metabolic pathway for 5-(4'-chloro-n-butyl)picolinic acid involves chain elongation of fatty acids, which is confirmed in various species.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

A novel metabolic pathway in the metabolism of 5-(4'-chloro-n-butyl)picolinic acid.

References

Use of stable isotopes in pharmacology‐clinical pharmacology

Stable isotopes offer advantages in pharmacology and clinical pharmacology due to their absence of radiation hazards, making their use safer and simpler for human studies.

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The artificially created cluster technique effectively quantifies serum levels of Mydocalm using a mixture of unlabeled and stable isotope labeled drugs.

Studies of urinary metabolites of 2-(4-isobutylphenyl) propionic acid by gas-liquid chromatography-mass spectrometry.

Urinary metabolites of ibuprofen are enriched in the ()-enantiomer and four other oxidative transformations of the isobutyl group.

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