Patterns of cytopathology and lysosomal enzyme release in poliovirus-infected HEp-2 cells treated with either 2-(alpha-hydroxybenzyl)-benzimidazole or guanidine HCl.

doi:10.1099/0022-1317-6-1-151

Paper

Patterns of cytopathology and lysosomal enzyme release in poliovirus-infected HEp-2 cells treated with either 2-(alpha-hydroxybenzyl)-benzimidazole or guanidine HCl.

Published 1970 · L. E. Guskey, P. Smith, D. A. Wolff

The Journal of general virology

Q2 SJR score

39

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0

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Abstract

Summary The viral inhibitors guanidine hydrochloride and 2-(α-hydroxybenzyl)-benzimidazole (HBB) were used to study the relationship between lysosomal enzyme release and the development of poliovirus-induced cytopathic effect (CPE) in HEp-2 cells. Lysosomal enzyme release, the development of CPE and virus replication were inhibited or delayed if these antiviral agents were added up to 2 to 3 hr after infection. When added later the agents were no longer effective. It is suggested that a virus-induced protein produced during 3 hr after infection is responsible for lysosomal enzyme release.

In Vitro Study

Study Snapshot

Antiviral agents guanidine hydrochloride and 2-(-hydroxybenzyl)-benzimidazole effectively inhibit or delay lysosomal enzyme release and poliovirus replication in HEp-2 cells when added up to 2 to 3 hours after infection.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Patterns of cytopathology and lysosomal enzyme release in poliovirus-infected HEp-2 cells treated with either 2-(alpha-hydroxybenzyl)-benzimidazole or guanidine HCl.

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