Paper
Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions.
Published Aug 24, 2007 · Yu Angell, K. Burgess
Chemical Society reviews
Q1 SJR score
484
Citations
2
Influential Citations
Abstract
This critical review concerns the impact of copper-mediated alkyne-azide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities (e.g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.
Highly CitedStudy Snapshot
Copper-mediated azide-azide cycloadditions enable the creation of less peptidic pharmaceutical leads by inserting triazoles into peptide chains and linking them to functionalities.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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