Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity.

doi:10.1016/J.BMC.2005.09.051

Paper

Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity.

Published Feb 15, 2006 · Suk-June Choi, H. Park, S. Lee

Bioorganic & medicinal chemistry

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93

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Abstract

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In Vitro Study

Highly Cited

Study Snapshot

2-(3-Amino-4-methylphenyl)benzothiazole shows high topoisomerase II inhibitory activity, comparable to etoposide, making it a potential cytotoxic agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity.

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