2-Chloro-5-bromopyridine was immobilized on polystyrene via selective introduction of a traceless silicon linker at the C-4 position. A useful scaffold was thus obtained, as demonstrated by efficient and selective reactions with polar and transition organometallic reagents, opening a new access to pyridine-based libraries of synthons and chromophores.

A 2-chloro-5-bromopyridine scaffold on polystyrene allows efficient and selective reactions with organometallic reagents, enabling the synthesis of pyridine-based synthons and chromophores.

Paper

Solid phase synthesis of pyridine-based derivatives from a 2-chloro-5-bromopyridine scaffold.

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