PRELUDIN (phenmetrazine hydrochloride) is a recently discovered agent employed in the treatment of obesity. Numerous reports have attested its value in weight reduction.1-3 It has sympathomimetic properties closely allied to those of ephedrine and amphetamine, and acts as an anorexic agent but with minimal side effects on the central nervous and cardiovascular systems. The problem of weight reduction in the obese diabetic is a difficult one. We were interested not only in the weight-reducing qualities of this agent but also in its effect on the diabetic state, particularly with respect to the blood glucose level and insulin requirements.

Phenmetrazine hydrochloride (preludin) effectively reduces weight in obese diabetics without causing significant side effects, and may also improve blood glucose levels and insulin requirements.

Paper

The use of phenmetrazine hydrochloride (preludin) in the obese diabetic.

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