The 1-cyclopropyl-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate was prepared by acyl-chlorination,condensation,decarboxylation,estherification,cyclopropylamine replacement and cyclization of 3-methoxyl-2,4,5-trifluorobenzoic acid with an overall yield of 48%.

This study presents a method for preparing 1-cyclopropyl-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate with a yield of 48%, offering potential applications in pharmaceutical and biotechnology industries.

Paper

Preparation of 1-cyclopropyl-6,7-difluoro-8-methyl-1, 4-dihydro-4-oxoquinoline-3-ethyl carboxylate

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