Preparation the Key Intermediate of Angiotensin‐Converting Enzyme (ACE) Inhibitors: High Enantioselective Production of Ethyl (R)‐2‐Hydroxy‐4‐Phenylbutyrate with Candida boidinii CIOC21

doi:10.1002/ADSC.200700420

Paper

Preparation the Key Intermediate of Angiotensin‐Converting Enzyme (ACE) Inhibitors: High Enantioselective Production of Ethyl (R)‐2‐Hydroxy‐4‐Phenylbutyrate with Candida boidinii CIOC21

Published Feb 22, 2008 · Yongzheng Chen, Hui Lin, Xiao‐Ying Xu

Advanced Synthesis & Catalysis

UNKNOWN SJR score

36

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2

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Abstract

Forty microorganisms belonging to different taxonomical groups were used to catalyze the enantioselective reduction of ethyl 2-oxophenylbutyrate to afford the corresponding ethyl 2-hydroxy-4-phenylbutyrate. Several microorganisms led to over 99% ee of ethyl (S)-2-hydroxy-4-phenylbutyrate. Especially, we firstly found that the Candida boidinii CIOC21 could be effectively used for the enantioselective preparation the ethyl (R)-2-hydroxy-4-phenyl-butyrate in pure aqueous medium with 99% ee, a key intermediate in the production of angiotensin-converting enzyme (ACE) inhibitors.

Study Snapshot

Candida boidinii CIOC21 effectively produces enantioselective ethyl (R)-2-hydroxy-4-phenyl-butyrate with 99% ee, a key intermediate in the production of angiotensin-converting enzyme (ACE) inhibitors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Preparation the Key Intermediate of Angiotensin‐Converting Enzyme (ACE) Inhibitors: High Enantioselective Production of Ethyl (R)‐2‐Hydroxy‐4‐Phenylbutyrate with Candida boidinii CIOC21

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