Preparation of (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine

doi:10.1016/J.TETASY.2015.06.021

Paper

Preparation of (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine

Published Sep 15, 2015 · M. Yamashita, Naohiro Taya, Mitsuyoshi Nishitani

Tetrahedron-asymmetry

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Abstract

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Study Snapshot

The novel triple reuptake inhibitor (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine monohydrochloride 1 can be synthesized in excellent yield using various enzymes, asymmetric hydrogenation catalysts, and

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Preparation of (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine

References

Novel triple reuptake inhibitors with low risk of CAD associated liabilities: design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds.

A novel triple reuptake inhibitor with low cationic amphiphilic drug liability potential, 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine, shows potent antidepressant-like effects in mice.

Effects of the triple reuptake inhibitor amitifadine on extracellular levels of monoamines in rat brain regions and on locomotor activity

Amitifadine increases serotonin, norepinephrine, and dopamine levels in rat brain regions associated with depression without causing locomotor hyperactivity or stereotypical behaviors.

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This study reports a chemoenzymatic asymmetric synthesis of antidepressant venlafaxine and its analogues using stereoselective cyanohydrin synthesis and lipase-catalyzed kinetic resolution.

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Enantioselective Synthesis of Chiral β-Aryloxy Alcohols by Asymmetric Hydrogenation of α-Aryloxy Aldehydes via Dynamic Kinetic Resolution

This study developed a catalytic enantioselective hydrogenation method for racemic -aryloxy aldehydes, resulting in high yields and moderate to good enantioselectivity.

Kinetic resolution of primary alcohols having remote stereogenic centers: lipase mediated kinetic resolution of (±)-3-chloro-3-arylpropanols

Lipase-mediated acetylation with CCL provides the best enantioselectivity for kinetic resolution of ()-3-chloro-3-arylpropanols, yielding enantiomerically enriched products with up to 78% ee.

Citations

Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates

Lipases have shown promising advancements in the synthesis of enantiomerically pure active pharmaceutical ingredients and their intermediates, offering an alternative to conventional chemical processes for producing single-isomer chiral drugs.