Green process development for the preparation of 2,6-dibromo-4-nitroaniline from 4-nitroaniline using bromide–bromate salts in an aqueous acidic medium

doi:10.1039/C6RA13680J

Paper

Green process development for the preparation of 2,6-dibromo-4-nitroaniline from 4-nitroaniline using bromide–bromate salts in an aqueous acidic medium

Published Sep 20, 2016 · Venkatanarayana Pappula, S. Adimurthy

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Abstract

An organic solvent-free process for the preparation of 2,6-dibromo-4-nitroaniline, (an important intermediate in the synthesis of azo disperse dyes) from 4-nitroaniline using 2 : 1 bromide–bromate salts under an aqueous acidic medium at ambient conditions has been developed. The 2 : 1 bromide–bromate couple could be obtained by mixing pure NaBr/NaBrO3 salts or by adjusting the 5 : 1 mole ratio of NaBr/NaBrO3 (obtained in an aqueous solution as an intermediate from the bromine manufacture industry by a cold process) to 2 : 1 by the addition of a suitable oxidant. After completion of the reaction the product was purified by simple filtration and washing with water. The aqueous acidic filtrate was recycled up to five times without loss of purity and yield of the product. The method was extended to other aromatic substrates.

Study Snapshot

This green process for preparing 2,6-dibromo-4-nitroaniline from 4-nitroaniline using bromide-bromate salts in an aqueous acidic medium allows for the production of azo disperse dye intermediates without using organic solvents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Green process development for the preparation of 2,6-dibromo-4-nitroaniline from 4-nitroaniline using bromide–bromate salts in an aqueous acidic medium

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