Production of 3-hydroxy fatty acids by the yeast Dipodascopsis uninucleata. Biological implications.

doi:10.1007/978-1-4615-4793-8_97

Paper

Production of 3-hydroxy fatty acids by the yeast Dipodascopsis uninucleata. Biological implications.

Published 1999 · J. Kock, P. Venter, A. Botha

Advances in experimental medicine and biology

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3

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Abstract

Hydroxy fatty acids (OH-FAs) including 3-OH-FA are widely distributed in microorganisms (Schweizer, 1989). Thus, the production of 3-OH-FA by fungi has been reported in various studies (Van Dyk et al., 1994). Using thin-layer chromatography, autoradiography, 1H-NMR as well as gas chromatography-mass spectrometry, we isolated and identified the novel 3-hydroxyeicosanoid (3R)-hydroxy-(5Z,8Z,llZ,14Z)-eicosatetraenoic acid (3-HETE) from the yeast Dipodascopsis uninucleata following incubation with arachidonic acid (Van Dyk et al., 1991; Venter et al., 1997). This compound now turned out to be the prototype of the new family of fungal unsaturated bioactive (3R)-hydroxy-oxylipins (see Nigam et al., this volume).

Study Snapshot

The yeast Dipodascopsis uninucleata produces a novel 3-hydroxyeicosanoid (3-HETE) that is a prototype of a new family of fungal unsaturated bioactive (3R)-hydroxy-oxylipins with potential biological effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Production of 3-hydroxy fatty acids by the yeast Dipodascopsis uninucleata. Biological implications.

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