Proline in the cerebrospinal fluid of normal subjects and Alzheimer's-disease patients, as determined with a new double-labeling assay technique.
C. Baxter, R. Baldwin, N. Pomara
Oct 1, 1984
Citations
6
Citations
Journal
Biochemical medicine
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Semantic Scholar
Key Takeaway Key Takeaway: Proline levels in cerebrospinal fluid of Alzheimer's disease patients show no significant difference from normal controls and do not consistently reflect cognitive deficits or symptomatic severity of the disease.
Abstract
Past studies have implicated proline involvement in the function of memory and learning. A new micromethod has been developed that is suitable for measuring proline accurately in as little as 0.1 ml of CSF. In normal human CSF, the average proline level was found to be consistently about 1.3 microM. In the CSF of patients with Alzheimer's disease and mixed dementias, the levels of proline showed no statistically significant difference from proline levels in the CSF of normal controls. Furthermore, the proline levels in the CSF of the Alzheimer's disease patients did not reflect, consistently, the cognitive deficits or the symptomatic severity of the disease. Proline levels in CSF showed no statistically significant change with the age of individuals tested.