Paper
The Antineoplastic Properties and Mechanism of Interaction of an Antioxidant, Sodium 2-Carboxy-2-(N-Aсetylamino)-3-(3,5-di-tert-Butyl-4-Hydroxyphenyl)Propionate, with Peptides in an Aqueous Environment According to the Data of the Calculation by Quantum Chemistry Methods
Published May 1, 2020 · A. Volodkin, V. Erokhin, E. Mil
Russian Journal of Physical Chemistry B
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Abstract
The antineoplastic properties of an antioxidant, sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, are studied on an ascites tumor, Sarcoma 37, and on a solid tumor, Lewis carcinoma. A full suppression of Sarcoma 37 and an intensification of apoptosis (a decrease in the level of Bcl-2 antiapoptotic protein) in the cells of Lewis carcinoma are observed for intraperitoneal injection of the preparation. The structure of the complexes of sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate with peptides is calculated using quantum chemistry. Quantitative data are obtained which characterize the intra- and intermolecular interactions of the above components in nanoassociates.
In Vitro StudySodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate effectively suppresses Sarcoma 37 and intensifies apoptosis in Lewis carcinoma cells, with its structure characterized
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