Paper
Protective effect of pomegranate fruit juice against Aeromonas hydrophila-induced intestinal histopathological changes in mice.
Published Jan 1, 2009 · S. Belal, A. Abdel-Rahman, D. Mohamed
World applied sciences journal
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Abstract
5 Abstract: Aeromonas hydrophila is a very prevalent species. It can cause both intestinal and nonintestinal infections in humans and can often be fatal. Moreover, in the recent years, naturally occurring antioxidant compounds have gained considerable attention as antibacterial agents. The present study aimed to investigate the possible protective effect of pomegranate fruit juice (PJ) against Aeromonas hydrophila- induced intestinal histopathological alterations as one of the edible safe natural products. Seventy-two adult MF1 male mice were used and divided into three groups; first group, control group, was injected with phosphate-buffered saline PBS at dose and intervals parallel to the treated groups. Second group was injected i.p. with purified lipopolysaccharides (LPS) extracted from Aeromonas hydrophila once a week for four weeks. Third group was injected with LPS suspension as second group and synergistically received drinking water supplemented with pomegranate fruit extract. The bacteria infected group showed severe deterioration in the intestinal mucosa in the form of villar atrophy, necrosis of apical enterocytes and wide destruction of crypt cells. At the ultrastructural level, many enterocytes showed completely damaged organelles and dissolved cytoskeletal. The treatment with pomegranate juice significantly and substantially prevented the intestinal histopathological changes and normalized its morphometric parameters. It was concluded that pomegranate juice holds great promise as antimicrobial and anti-inflammatory new therapeutic. Also, we advise use of pomegranate in human nutrition as table fruit or juice for its antioxidant qualities.
RCT
Animal StudyPomegranate fruit juice effectively prevents intestinal histopathological changes caused by Aeromonas hydrophila, offering potential as an antimicrobial and anti-inflammatory new therapeutic.
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