The preparation and biological activities of a series of pyrido[3,4-e]-1,2,4-triazines, 1,2,4-triazino[5,6-c]quinolines, and related fused triazines are described. Methyl, amino, and acylamino substituents were placed in the pyridyl ring of the former system. Other structural modifications included various alkyl, cycloalkyl, substituted phenyl, and heterocyclic groups in the 3-position of these ring systems. In agar dilution assays, actives in this series inhibited strains of Candida, Aspergillus, Mucor, and Trychophyton species at MIC's of less than or equal to 16 micrograms/mL.

Pyrido[3,4-e]-1,2,4-triazines show potential as antifungal agents, inhibiting strains of Candida, Aspergillus, Mucor, and Trychophyton at MIC levels less than or equal to 16 micrograms/mL.

Paper

Pyrido [3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents.

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