The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.

Quinoxalinediones are potent and competitive antagonists at non-NMDA glutamate receptors, aiding in understanding their structure-activity relations and their role in synaptic transmission in the mammalian brain.

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Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

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