[Reactivation by 1-hydroxyimino-4-methyl-2-pentamone of plasma cholinesterases in the dog inhibited by different orgenophosphates].

Paper

[Reactivation by 1-hydroxyimino-4-methyl-2-pentamone of plasma cholinesterases in the dog inhibited by different orgenophosphates].

Published Jul 1, 1975 · E. Fournier, D. Q. Quan, M. Sonnier

European journal of toxicology and environmental hygiene. Journal europeen de toxicologie

UNKNOWN SJR score

1

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Abstract

The hydroxyimino-1 methyl-4 pentanone-2 was selected among several oximes because of its highly successful restoring action on dog plasmatic cholinesterases inhibited by DFP (diisopropyl fluorophosphate). During the in vitro study, this storing action was tested on 10 organophosphates. Results are compared to those obtained when contrathion is used.

In Vitro Study

Study Snapshot

1-hydroxyimino-4-methyl-2-pentamone effectively restores dog plasmatic cholinesterases inhibited by DFP, demonstrating its potential as a safer alternative to contrathion for treating cholinesterase inhibitors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

[Reactivation by 1-hydroxyimino-4-methyl-2-pentamone of plasma cholinesterases in the dog inhibited by different orgenophosphates].

References

Citations

Toxicological considerations of acetylcholinesterase reactivators

Oximes' antidotal efficacy is limited by their physico-chemical properties and tissue-specific distribution, with increased penetration of biological barriers potentially introducing significant risks due to their intrinsic toxicity.