4-Hydroximinomethyl-pyrimidine (VIII) has been prepared from 4-methylpyrimidine (III) by nitrosation or, more preferably, by the Ortoleva-King procedure. The oxime VIII has a syn configuration and yields, upon alkylation with iodomethane, 4-hydroximinomethyl-1-methyl-pyrimidinium iodide (IX). The latter proved to be a reactivator of phosphorylated acetylcholine esterase in vitro. In combination with low doses of atropine it also protected mice against organophosphate intoxication.

4-Hydroxyminomethyl-1-methyl-pyrimidinium iodide (IX) is a potent reactivator of phosphorylated acetylcholine esterase and protects mice against organophosphate intoxication when combined with low doses of atrop

Paper

Reactivators of Inhibited Acetylcholinesterase. I. the Preparation and Properties of 4‐Hydroxyminomethyl‐1‐Methylpyrimidinium Iodide

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