O. Sørensen, A. Schmidtchen, K. Roupé
Oct 1, 2008
Expert Review of Dermatology
The skin constitutes an innate immunity barrier against surrounding microbes. This barrier is disrupted when wounding/injury occurs. The subsequent wound healing is divided broadly into the overlapping stages of coagulation, inflammation, proliferation and tissue remodeling. The EGF receptor (EGFR) is activated after cutaneous injury. This review highlights the role of the EGFR in the innate immune defense of the cutaneous wound. Activation of the EGFR establishes one of the molecular links between injury and the subsequent neutrophil influx, expression of antimicrobial (poly)peptides and the re-establishment of the physical barrier.