Paper
RELATIONSHIP BETWEEN SLEEP APNEA AND TARGET ORGAN DAMAGE IN NEVER TREATED HYPERTENSIVE PATIENTS: PP.35.476
Published Jun 1, 2010 · E. Florczak, A. Januszewicz, A. Prejbisz
Journal of Hypertension
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Abstract
Objective: To establish the relationship between the obstructive sleep apnea (OSA) and target organ damage in patients with never treated hypertension. Design and Methods: We investigated 121 patients with never treated hypertension (96 M, 25F; mean age 35,9+/−10,1 range 18–58yrs). In all patients metabolic syndrome (MS) components as well as albuminuria were assessed. MS was diagnosed according to ESH/ESC 2007 guidelines. All patients underwent polysomnography - apnea/hypopnea index (AHI) was calculated. Left ventricular mass index (LVMI) and echocardiography including tissue Doppler indices (DT, IVRT, E, Eprim, Aprim, E/Eprim) were calculated. The intima-media thickness of the common carotid arteries (CIMT) was measured. RI and PI were measured in Doppler duplex examination of renal arteries. Results: Mild (AHI 5-15), moderate (AHI 15-30) and severe (AHI>30) OSA was diagnosed respectively in 29,9%, 12,8% and 6,8% patients. Patients were divided into 3 groups: group 1 - without OSA, group 2 - with mild OSA and group 3 - with moderate-severe OSA. MS was more frequent in the groups 2 and 3 as compared with the group 1 (41,9% and 68,2% vs. 23,4%; p < 0,01). Group 3 was characterized by more pronounced IMT as compared with groups 1 and 2 (743 um vs. 612 and 602 um; p < 0,01) and by non-significantly higher albuminuria in 24-h collection. IMT was higher in the group 3 both in patients with and without MS as compared with groups 1 and 2. There were no differences in echocardiographic indices except higher E/Eprim ratio and faster Eprim velocity in group 3 as compared with the groups 1 and 2. E/Eprim was higher in patients in the group 3 only in patients with MS. There were no differences in RI and PI and GFR between the groups. Conclusions: In our studied group of never treated hypertensive patients, patients with mild and moderate OSA were characterized by more frequent MS and more pronounced organ damage. The relationship between OSA and IMT was independent of MS.
Observational Study
Rigorous JournalIn never treated hypertensive patients, mild and moderate sleep apnea is associated with more frequent metabolic syndrome and more pronounced organ damage, while the relationship between OSA and IMT is independent of MS.
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