Reply to Eisenhut.
E. Shabani, G. Vercellotti, C. John
Dec 19, 2014
Citations
1
Citations
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Full text
Semantic Scholar
Key Takeaway Key Takeaway: Serum troponin levels in children with HPeV-3 infection may indicate a variety of cardiac abnormalities, but the cause of these abnormalities remains unclear.
Abstract
TO THE EDITOR—We thank Dr Eisenhut for his comments regarding possible myocarditis associated with human parechovirus-3 (HPeV-3) infection [1]. With respect to the cohort of 118 children we reported on from New South Wales, Australia [2], and further review of the medical records, 10 children had transthoracic echocardiograms that did not demonstrate evidence of myocarditis. All evaluations were performed in young infants aged 5–95 days at presentation. Eight children had serum troponin levels measured and 6 of these were >50 ng/L on at least 1 occasion (highest 189 ng/L). Four of the children with raised troponin levels also had echocardiograms. Two other children had normal serum creatinine kinase levels. At least 19 children had electrocardiograms (ECGs), the majority of which showed sinus tachycardia only. One ECG demonstrated supraventricular tachycardia in a child who also had an echocardiogram (only abnormality was a patent foramen ovale), both of which were normal on follow-up. Another ECG demonstrated occasional ventricular ectopics and sinus tachycardia. One child diagnosed with severe left ventricular dysfunction due to a congenital cardiac defect had an abnormal ECG, and serum troponin peaked at 7125 ng/L. She required