Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers.

doi:10.1021/JM00366A025

Paper

Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers.

Published Dec 1, 1983 · C. Demerson, L. Humber, N. Abraham

Journal of medicinal chemistry

Q1 SJR score

78

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0

Influential Citations

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Abstract

Etodolac, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, a clinically effective analgesic and antiinflammatory agent, has been resolved via a chromatographic separation of its diastereoisomeric esters with (-)-borneol. The effects of the enantiomers were studied in vitro on prostaglandin synthetase and on adjuvant-induced arthritis in rats. The biochemical and pharmacological results show that virtually all of the effects of etodolac are due to the (+) enantiomer.

In Vitro Study

Highly Cited

Study Snapshot

Etodolac's analgesic and antiinflammatory effects are mainly due to the (+) enantiomer, which inhibits prostaglandin synthetase and is effective in treating arthritis in rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers.

References

Citations

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Copper-catalyzed domino cascade reaction effectively synthesizes dihydropyrano[2.3-b]indol-4(9H)-ones, with the 4-benzyloxy group of indole substrates acting as a guiding group for promoting cyclization under

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