Seven derivatives of 3,4,5‐trimethoxybenzoic acid have been prepared and tested for their ability to potentiate barbiturate hypnosis in mice, to deplete the 5‐hydroxytryptamine content of rat brain, and to exert a hypotensive action on the cat blood pressure. The only derivative to exert all three actions is the simple anilide, 3,4,5‐trimethoxybenzanilide, which is about 8 times less active than reserpine. The anilide, N‐(3,4‐dimethoxyphenethyl)‐3,4,5‐trimethoxybenzamide, is also about 8 times less active than reserpine in the first two tests but it raises the blood pressure.

3,4,5-trimethoxybenzanilide effectively potentiates barbiturate hypnosis, depletes 5hydroxytryptamine, and reduces cat blood pressure, while N-(3,4-dimethoxyphenethyl)-3,4,5-trimethoxybenzamide

Paper

Potential resperine analogues. Part II. 3,4,5-Trimethoxybenzoic acid derivatives.

References

Citations