Cardiovascular and respiratory effects of cannabis in cat and rat

doi:10.1111/j.1476-5381.1973.tb08262.x

Paper

Cardiovascular and respiratory effects of cannabis in cat and rat

Published Sep 1, 1973 · J. Graham, D. Li

British Journal of Pharmacology

Q1 SJR score

104

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1

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Abstract

1 In anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), Δ1‐tetrahydrocannabinol (THC) (0·5 mg/kg) and Δ6‐THC (0·5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate. 2 Neither cannabinol (1 mg/kg, i.v.) nor cannabidiol (1 mg/kg, i.v.) had any observed effects on the cardiovascular and respiratory systems of the rat. 3 Pretreatment of rats with atropine (1 mg/kg, i.v.) reduced the hypotension and bradycardia caused by Δ1‐THC or the extract. 4 In anaesthetized cats with autoperfused hindquarters, cannabis extract (10 mg/kg, i.v.) and Δ1‐THC (0·2 mg/kg, i.v.) caused hypotension, bradycardia, depression of respiratory rate and reduction of hindlimb perfusion pressure. 5 Both cannabis extract and Δ1‐THC potentiated reflex vasodilatation and direct vasoconstriction in the hindlimb induced by intravenous noradrenaline in the cat; they reduced reflex hindlimb vasoconstriction elicited by histamine, acetylcholine or bilateral carotid occlusion. 6 Tolerance to these cardiovascular and respiratory effects of cannabis extract developed in rats which had been treated i.p. with the extract at (50 mg/kg) per day for 14 days.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Key takeawayCannabis extract and 1-THC cause hypotension, bradycardia, and respiratory depression in anaesthetized rats and cats, with tolerance developing after 14 days of treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Cardiovascular and respiratory effects of cannabis in cat and rat

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