Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation
Published Nov 17, 2014 · Jian Wang, Fengqi Li, Haiming Wei
The Journal of Experimental Medicine
Q1 SJR score
352
Citations
13
Influential Citations
Abstract
Wang et al. examine how influenza A virus causes GI symptoms. Intranasal infection in mice causes intestinal pathology via virally activated CD4 T cells in the lung up-regulating CCR9 and migrating to the intestine where they secrete IFN-γ that alters homeostasis of the microbiota. Subsequent induction of IL-15 aids differentiation into pathogenic Th17 cells in the gut.
Study Snapshot
Key takeawayInfluenza A virus infection causes intestinal immune injury by altering microbiota homeostasis and inducing pathogenic Th17 cells in the gut.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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