Rocuronium 0.3 mg·kg−1 (ED95) induces a normal peak effect but an altered time course of neuromuscular block in patients with Duchenne's muscular dystrophy

doi:10.1111/j.1460-9592.2006.01870.x

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Rocuronium 0.3 mg·kg−1 (ED95) induces a normal peak effect but an altered time course of neuromuscular block in patients with Duchenne's muscular dystrophy

T. Muenster, Joachim W. Schmidt, S. Wick

Aug 1, 2006

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Journal

Pediatric Anesthesia

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Key Takeaway

Key Takeaway: Rocuronium 0.3 mgkg1 (ED95) has a normal peak effect but an altered time course of neuromuscular block in Duchenne's muscular dystrophy patients.

Abstract

Background: In patients with Duchenne's muscular dystrophy (DMD) recovery from neuromuscular block is delayed. It has been assumed that this is because of a higher potency of muscle relaxants in this patient cohort. We determined the peak effect, and the time course of action of rocuronium 0.3 mg·kg−1 (ED95) in DMD patients.

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