Objective:To investigate the role of matrix metalloproteinase-10(MMP-10) on the invasion of human bladder cancer in vitro.Methods:siRNA against MMP-10 gene and negative control siRNA were synthesized,and transfected into human bladder cancer T24 cell line,which has high invasive potential in vitro,.The expression of MMP-10 was detected by RT-PCR and Western blot,while the invasive potential in vitro was also compared by transwell assay.Results:siRNA against MMP-10 gene effectively inhibited the expression of MMP-10 as well as the in vitro invasive potential of bladder cancer T24 cell.Conclusion:MMP-10 may promote the invasion and metastasis in bladder cancer.Inhibition of MMP-10 may provide a new basis for the prevention and treatment of metastatic bladder cancer.

MMP-10 may promote bladder cancer invasion and metastasis, and inhibiting MMP-10 may provide a new basis for preventing and treating metastatic bladder cancer.

The role of matrix metalloproteinase-10(MMP-10) on the invasion of human bladder cancer T24 cell line in vitro

Key Takeaway: MMP-10 may promote bladder cancer invasion and metastasis, and inhibiting MMP-10 may provide a new basis for preventing and treating metastatic bladder cancer.