Paper
Role of BAX in the apoptotic response to anticancer agents.
Published Nov 3, 2000 · Lin Zhang, Jian Yu, B. Park
Science
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Citations
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Influential Citations
Abstract
To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were partially resistant to the apoptotic effects of the chemotherapeutic agent 5-fluorouracil, but apoptosis was not abolished. In contrast, the absence of BAX completely abolished the apoptotic response to the chemopreventive agent sulindac and other nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibited the expression of the antiapoptotic protein Bcl-XL, resulting in an altered ratio of BAX to Bcl-XL and subsequent mitochondria-mediated cell death. These results establish an unambiguous role for BAX in apoptotic processes in human epithelial cancers and may have implications for cancer chemoprevention strategies.
In Vitro Study
Highly CitedBAX plays a crucial role in apoptosis in human epithelial cancers, potentially impacting cancer chemoprevention strategies.
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