A series of salicylaldehydes have been prepared through the replacement of the easily leaving chlorine atom in 5-chloromethyl-2-hydroxybenzaldehyde with various O-, S- or N-nucleophiles. The involvement of a few of these salicylaldehydes in the synthesis of heterocycles such as benzofuran or coumarin, or as substrate in the Petasis borono-Mannich reaction has been explored.

Salicylaldehydes derived from 5-chloromethyl-2-hydroxybenzaldehyde can be used in the synthesis of heterocycles like benzofuran and coumarin, or as substrates in the Petasis borono-Mannich reaction.

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Salicylaldehydes Derived from 5-Chloromethyl-2-hydroxybenzaldehyde – Synthesis and Reactions

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