SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression
Published Apr 15, 2017 · Kaixiang Cao, Clayton K. Collings, Stacy A. Marshall
Genes & Development
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Abstract
In this study, Cao et al. identify two cis-regulatory elements (E1 and E2) functioning as shadow enhancers to regulate the early expression of the HoxA genes. Their results reveal multiple regulatory layers for Hox genes to fine-tune transcriptional programs essential for development.
Study Snapshot
Key takeawayTwo cis-regulatory elements (E1 and E2) function as shadow enhancers to regulate early expression of HoxA genes, revealing multiple regulatory layers for Hox genes essential for development.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.