Paper
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid.
Published Oct 18, 2004 · I. Stansfield, Salvatore Avolio, S. Colarusso
Bioorganic & medicinal chemistry letters
Q2 SJR score
37
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0
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Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid shows 10-fold improved activity as a hepatitis C virus NS5B polymerase inhibitor, with a trifluoromethyl acylsulfonamide group as a viable replacement for the
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Novel 1,3-alternate calix[4]arene-bis(crown-6-ethers) with proton-ionizable groups enhance extraction efficiency and maintain high Cs+ selectivity in solvent extraction of alkali metal cations.
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Citations
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Targeting HIV/HCV Coinfection Using a Machine Learning-Based Multiple Quantitative Structure-Activity Relationships (Multiple QSAR) Method
The multiple QSAR method effectively predicts chemical-protein interactions, identifying potential multitarget inhibitors for treating HIV/HCV coinfection.
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Targeting against HIV/HCV Co-infection using Machine Learning-based multitarget-quantitative structure-activity relationships (mt-QSAR) Methods
The mt-QSAR method accurately predicts chemical-protein interactions, potentially leading to the discovery of multitarget inhibitors for HIV/HCV co-infection treatment.
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Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle.
Small molecules acting as bioisosteres of pyrophosphate can selectively freeze HIV-1 reverse transcriptase's catalytic cycle, potentially offering a new treatment for HIV infections.
2018·9citations·Cyrus M Lacbay et al.·Bioorganic & medicinal chemistry
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