In experiments on canine kidneys, cortical edema formation during hypothermic storage following a period of normothermic ischemia of up to 30 min duration was - according to the osmolality of the perfusion fluid - lower after flush perfusion with Sacks II solution than with Biotest-"Collins" solution or Ringer-mannitol solution, which resulted in the highest edema. The adenine nucleotide content fell corresponding to the duration of the hypothermic storage or the duration of an initial normothermic ischemia, but only small further changes were found during storage following initial normothermic damage. Moreover, with respect to the maintenance of nucleotide contents the strong hyperosmolar intracellular solutions were not superior to Ringer-mannitol solution of 330 mosmol/liter.

Hypothermic storage of dog kidneys with Sacks II solution reduces cortical edema formation, while Ringer-mannitol solution maintains nucleotide contents.

[Metabolic status of hypothermically stored dog kidneys with various perfusion solutions and ischemia pretreatment].

Key Takeaway: Hypothermic storage of dog kidneys with Sacks II solution reduces cortical edema formation, while Ringer-mannitol solution maintains nucleotide contents.