Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization.
Published Jan 20, 2016 · Fangjun Xiong, Haifeng Wang, Lingjie Yan
Organic & biomolecular chemistry
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Abstract
A novel, stereoselective approach towards rosuvastatin calcium from the known (S)-homoallylic alcohol has been developed. The synthesis is highlighted by a regio- and stereocontrolled ICl-induced intramolecular cyclization of chiral homoallylic carbonate to deliver the C6-formyl statin side chain with a syn-1,3-diol moiety. An improved synthesis of the rosuvastatin pyrimidine core moiety is also included. Moreover, this methodology is useful in the asymmetric synthesis of structural variants of statins such as pitavastatin calcium and atorvastatin calcium and their related analogs.
Study Snapshot
Key takeawayThis study developed a novel, stereoselective approach for rosuvastatin calcium synthesis using iodine chloride-induced intramolecular cyclization, which can also be applied to asymmetric synthesis of statin variants like pitavastatin calcium and atorvastatin calcium
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.