Paper
A new strategy for taste masking on bitter drug by other combined drug in fixed‐dose combination: bitterness of Amlodipine besylate could be masked efficiently by Valsartan
Published Jul 5, 2019 · Honami Kojima, Saki Nakamura, T. Haraguchi
Journal of Pharmacy and Pharmacology
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Abstract
The aim of this study was to evaluate the bitterness of amlodipine besylate (AML) combined with other five antihypertensive drugs: alacepril, benazepril, hydrochlorothiazide, telmisartan (TEL) and valsartan (VAL), which have possibility of usage as a fixed‐dose combination (FDC) drugs.
Study Snapshot
Key takeawayValsartan effectively masks the bitterness of amlodipine besylate in fixed-dose combination with other antihypertensive drugs, making it a promising strategy for taste masking in fixed-dose combination drugs.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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