Studies of hepatic excretory function. The effect of 17alpha-ethyl-19-nortestosterone on sulfobromophthalein sodium (BSP) metabolism in man.

doi:10.1172/JCI104727

Paper

Studies of hepatic excretory function. The effect of 17alpha-ethyl-19-nortestosterone on sulfobromophthalein sodium (BSP) metabolism in man.

Published Mar 1, 1963 · J. Scherb, M. Kirschner, I. Arias

The Journal of clinical investigation

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42

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Abstract

The administration of large doses of 17a-ethyl19-nortestosterone to man is frequently associated with hyperbilirubinemia, with conjugated bilirubin in the serum and increased retention of sulfobromophthalein (BSP) in the serum 45 minutes after the intravenous administration of 5 mg BSP per kg body weight (1). Light microscopy studies of hematoxylin- and eosin-stained sections of liver reveal normal liver cells with occasional canalicular bile casts (2). Treatment of rats with 17a-ethyl-19-nortestosterone results in reduced capacity to excrete BSP and conjugated bilirubin in the bile (3). These observations suggest that the steroid may functionally inter

Study Snapshot

Hepatic excretory function may be impaired by 17a-ethyl-19-nortestosterone, leading to increased retention of sulfobromophthalein and conjugated bilirubin in the serum.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Studies of hepatic excretory function. The effect of 17alpha-ethyl-19-nortestosterone on sulfobromophthalein sodium (BSP) metabolism in man.

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