[Experimental study of the antiarrhythmic properties of zoniporide].

Paper

[Experimental study of the antiarrhythmic properties of zoniporide].

Published 2014 · A. Spasov, Gurova, A. Timofeeva

Eksperimental'naia i klinicheskaia farmakologiia

Q4 SJR score

1

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0

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Abstract

The antiarrhythmic properties of the Na+/H(+)-exchanger inhibitor zoniporide have been studied in experiments on rats. On the model of 45-min myocardial ischemia followed by 45-min reperfusion, the drug produced a significant (two-fold) decrease in the intensity of post-reperfusion arrhythmias (p < or = 0.05). On the model of 7-min ischemia followed by 5-min reperfusion, zoniporide prevented the development of ventricular fibrillation in 71.43% of cases as compared to control (p < or = 0.05). The drug also increased the threshold of electrical fibrillation by 69.23% and reduced the time to recovery of the heart rhythm by 37.85%.

Non-RCT

Animal Study

Study Snapshot

Zoniporide effectively prevents ventricular fibrillation and increases the threshold of electrical fibrillation in rats after myocardial ischemia and reperfusion, improving heart rhythm recovery.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

[Experimental study of the antiarrhythmic properties of zoniporide].

References

Citations

Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors

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