Suppression of the action potential in nerve by nitrobenzene derivatives.

doi:10.1073/PNAS.60.2.470

Paper

Suppression of the action potential in nerve by nitrobenzene derivatives.

Published Jun 1, 1968 · I. Cooke, J. Diamond, A. Grinnell

Proceedings of the National Academy of Sciences of the United States of America

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17

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Abstract

This study is concerned with the effects of three nitrobenzene derivatives on the excitatory properties of nerve. The stimulus for these studies arose from the observation by Berg, Diamond, and Marfey' that two of these derivatives specifically modify the Na+ and K+ permeability of erythrocytes, and from the fact that nerve action potentials depend upon specific changes in Na+ and K+ permeability. While several specific inhibitors of action potentials are tetrodotoxin, tetraethylammonium (TEA) ion), these are generally substances whose chemical interactions with the nerve membrane are difficult to predict. The nitrobenzene derivatives have the advantage of well-understood reaction chemistry, and two of them form a colored product at the reacted site, so compounds nerve insights.

Study Snapshot

Nitrobenzene derivatives can suppress nerve action potentials by altering Na+ and K+ permeability in erythrocytes, offering potential insights into nerve excitatory properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Suppression of the action potential in nerve by nitrobenzene derivatives.

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