Syntheses, additioneliminations, and additiondisplacements of 5-(bromomethylene)hydantoins

doi:10.1016/S0040-4039(03)01121-3

Paper

Syntheses, additioneliminations, and additiondisplacements of 5-(bromomethylene)hydantoins

Published Jun 30, 2003 · N. C. Mathur, Sau K. Wong, H. Shechter

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Abstract

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Study Snapshot

5-(bromomethylene)hydantoins can undergo acid-catalyzed reactions with nucleophiles through addition-displacement and addition-elimination processes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Syntheses, additioneliminations, and additiondisplacements of 5-(bromomethylene)hydantoins

References

Spectacular differences in the thermal behavior and the aromatic substitution reactions of 5-diazouracil and 5-diazo-3-methyluracil

5-diazo-3-methyluracil reacts with benzenes to yield 3-methyl-5-aryluracils, while 5-diazouracil thermolyzes to form (2,5-dioxo-3-imidazolin-4-yl) methylene, which

Citations

Homogeneous palladium-catalyzed enantioselective hydrogenation of 5-methylenhydantoin for the synthesis of L-Valine

Homogeneous palladium-catalyzed enantioselective hydrogenation of 5-methylenhydantoin allows for the synthesis of L-Valine with a 70% enantiomeric excess, with partial racemization observed upon hydrolysis and recovery.

Naturally occurring bioactive 5-ethylidenehydantoins as inspiration for the development of analogues

5-ethylidenehydantoin analogues with up to 82% yields were synthesized from readily available components, exhibiting extensive biological activities.

Synthesis and reactivity of 5-methylenehydantoins

5-Methylenehydantoins can undergo various reactions and are poor electron-withdrawing groups, requiring Lewis acids for conjugate addition reactions.

3‐Bromopyruvic Acid

3Bromopyruvic Acid is a colorless to light beige powder with a molar mass of 166.9 g/mol and a boiling point of 78-82°C.