Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells
Published Nov 1, 1997 · S. Tasaka, H. Tanabe, Y. Sasaki
Journal of Heterocyclic Chemistry
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Abstract
We have investigated 3-substituted-2-phenylimidazo[2,1-b]benzothiazole derivatives and herein we have discussed their pharmaceutical activities. We found that some 2-phenyl-5,6,7,8-tetrahydroimidazo[2,1-b]-benzothiazoles could overcome multidrug resistance for tumor cells. Among them, 2-phenyl-3-(N-methyl-3-piperidyl)carbonylammomiinomemyl-5,6,7,8-tetrahydVoimidazo[2,1-b]benzothiazole [N276-12] demonstrated the most potent activity for overcoming multidrug resistance.
Study Snapshot
Key takeaway2-phenyl-5,6,7,8-tetrahydroimidazo[2,1-b]-benzothiazoles can overcome multidrug resistance for tumor cells, with 2-phenyl-3-(N-methyl-3-piperidyl)carbonylammomiinomemyl
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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