A catalytic enantioselective bromocyclization of olefinic amides using amino-thiocarbamates as the catalysts has been developed. The resulting enantioenriched 2-substituted 3-bromopiperidines can readily be transformed to 3-substituted piperidines through a silver salt-mediated rearrangement. This process has been applied to the synthesis of a dopaminergic drug, Preclamol.

This study developed a catalytic enantioselective bromocyclization process using amino-thiocarbamates, which can be applied to the synthesis of dopaminergic drugs like Preclamol.

Paper

Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process.

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