2-Bromobenzaldehyde reacts with phenols in acetonitrile under carbon monoxide pressure in the presence of a catalytic amount of bis(triphenylphosphine)palladium(II) chloride to afford the corresponding 3-phenoxy-1,3-dihydro-1-isobenzofuranones in high yields.

This method enables the synthesis of 3-phenoxy-1,3-dihydro-1-isobenzofuranones in high yields by catalyzing carbonylative cyclization of 2-bromobenzaldehyde with phenols under carbon monoxide pressure.

Paper

Synthesis of 3‐phenoxy‐1,3‐dihydro‐1‐isobenzofuranones by palladium‐catalyzed carbonylative cyclization of 2‐bromobenzaldehyde with phenols

References

Citations