An Efficient Synthesis of 3-Amino-4-Fluorobutanoic Acid, an Inactivator of GABA Transaminase

doi:10.1080/00397918508063815

Paper

DOI: 10.1080/00397918508063815

An Efficient Synthesis of 3-Amino-4-Fluorobutanoic Acid, an Inactivator of GABA Transaminase

Published Apr 1, 1985 · J. Mathew, B. Invergo, R. Silverman

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Abstract

Abstract 3-Amino-4-fluorobutanoic' acid (1), a potent in vivo-inactivator of GABA transaminase, is synthesized in two steps. The lithium salt of tert-butyl acetate is condensed with fluoroacetonitrile and the product is reduced with sodium cyanoborohydride in acidic methanol to 1.

Study Snapshot

3-Amino-4-Fluorobutanoic Acid is a potent in vivo-inactivator of GABA transaminase, with a facile two-step synthesis process.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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