The antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides and their 3-substituted analogs has been studied. The initial acid was obtained by an effective one-pot method using the reaction of thiourea with maleic anhydride in hydrochloric acid. The maximum anti-staphylococcal activity was exhibited by N-[5-(R-benzyl)thiazol-2-yl]-2-(2,4-dioxothiazolidin-5-yl)acetamides.

The 2,4-dioxothiazolidine-5-acetic acid amides show maximum anti-staphylococcal activity, with N-[5-(R-benzyl)thiazol-2-yl]-2-(2,4-dioxothiazolidin-5-

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Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides

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