Synthesis and biological activity of 1,4-dihydrobenzothiopyrano[4,3-c]pyrazole derivatives, novel pro-apoptotic mitochondrial targeted agents.

doi:10.1016/j.bmc.2008.10.067

Paper

DOI: 10.1016/j.bmc.2008.10.067

Synthesis and biological activity of 1,4-dihydrobenzothiopyrano[4,3-c]pyrazole derivatives, novel pro-apoptotic mitochondrial targeted agents.

Published 2009 · L. Dalla Via, A. Marini, S. Salerno

Bioorganic & medicinal chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

The synthesized 1,4-dihydrobenzothiopyrano[4,3-c]pyrazole derivatives effectively inhibit cell growth by inducing mitochondrial permeability transition and triggering caspase activation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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