The vicinal amino alcohol is a common motif in natural products and pharmaceuticals. Amino acids constitute a natural, inexpensive, and enantiopure choice of starting material for the synthesis of such functionalities. However, the matters concerning diastereoselectivity are not obvious. This Perspective takes a look in the field of diastereoselective synthesis of vicinal amino alcohols starting from amino acids using various methods.

Diastereoselective synthesis of vicinal amino alcohols from amino acids offers a natural, inexpensive, and enantiopure starting material for natural products and pharmaceuticals, but diastereoselectivity remains a challenge.

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Diastereoselective synthesis of vicinal amino alcohols.

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