A series of novel 2-carboxylic acids of the title ring systems has been synthesized from the corresponding 3-acetyl-4H-[1]benzopyran-4-one and benzothiopyran-4-one. These acids were examined for their ability to inhibit the rat passive cutaneous anaphylaxis; the pyridinone carboxylic acids 6 displayed a higher degree of iv and ip anaphylactic activities than their pyranone analogues 5. The potassium salt 5a (R6 = K) was the only compound that exhibited a moderate oral activity.

Novel 2-carboxylic acids synthesized from 3-acetyl-4H-[1]benzopyran-4-one and benzothiopyran-4-one show antiallergic properties, with pyridinone carboxylic acids showing higher iv and ip anaphylactic activities than

Journal of medicinal chemistry

Synthesis and antiallergic properties of some 4H,5H-pyrano[3,2-c][1]benzopyran-4-one, 4H,5H-[1]benzothiopyrano[4,3-b]pyran-4-one, and 1,4-dihydro-5h-[1]benzothiopyrano[4,3-b]pyridin-4-one derivatives.

Paper

Synthesis and antiallergic properties of some 4H,5H-pyrano[3,2-c][1]benzopyran-4-one, 4H,5H-[1]benzothiopyrano[4,3-b]pyran-4-one, and 1,4-dihydro-5h-[1]benzothiopyrano[4,3-b]pyridin-4-one derivatives.

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