Synthesis and Antihypoxic Activity of 4-Hydroxy-6,7-Dimethoxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxylic Acid N-R-Amide Hydrochlorides

doi:10.1007/s11094-014-1156-x

Paper

Synthesis and Antihypoxic Activity of 4-Hydroxy-6,7-Dimethoxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxylic Acid N-R-Amide Hydrochlorides

Published Nov 28, 2014 · I. Ukrainets, E. Mospanova, A. Davidenko

Pharmaceutical Chemistry Journal

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Abstract

With the aim of identifying new biologically active substances with antihypoxic actions, the methyl ester of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid was reacted with dialkylaminoalkylamines for the targeted synthesis of a series of corresponding N-R-amides, obtained as hydrochlorides with good solubility in water. Primary pharmacological screening demonstrated structural-biological relationships of importance for future testing. As essentially nontoxic substances, several of the resulting amides showed high antihypoxic effects. One of these compounds, 3-(morpholin-4-yl)-propylamide 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrochloride, is suitable for further pharmacological testing as a potential antioxidant.

Study Snapshot

The synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid N-R-amide hydrochlorides resulted in several nontoxic compounds with high antihypoxic effects, one of which shows potential as a potential antioxidant

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Antihypoxic Activity of 4-Hydroxy-6,7-Dimethoxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxylic Acid N-R-Amide Hydrochlorides

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